Could the Sigma-1 Receptor Explain SSRI Withdrawal?

Exploring a neglected pathway with major implications for tapering

Dec 10 • Brooke Siem

10

3

November 2025

160. The Real World Harms of Post SSRI Sexual Dysfunction

A conversation with Angie Peacock

Nov 13 • Brooke Siem

7

2

1

October 2025

159. Psychiatric Drugs Interlude: The Real World is Where the Harms Live

A roundtable discussion between Brooke Siem, Dr. David Healy, Angie Peacock, David Antonuccio, PhD., and Kim Witzak

Oct 30 • Brooke Siem

6

2

158. Why SSRIs Aren't Actually Interchangeable

We’ve spent decades chasing “low serotonin,” when we should have been asking which serotonin systems each drug disrupts.

Oct 14 • Brooke Siem

16

5

157. SSRIs and the False Comfort of Selectivity

Rebranding SSRIs as Systemic Sabotage of Real Intelligence.

Oct 3 • Brooke Siem

12

2

2

September 2025

156. Why SSRI Withdrawal Feels Systemic: It’s About Energy, Not Emotions

Serotonin’s real job is keeping your cells powered under stress — and SSRIs disrupt that balance. Making sense of Chris Masterjohn's work in the context…

Sep 16 • Brooke Siem

18

5

5

August 2025

155: Here’s what serotonin actually does in your body—and why that matters for antidepressant withdrawal.

Unpacking Part III of Chris Masterjohn, PhD's work on serotonin and SSRIs

Aug 20 • Brooke Siem

18

6

4

154. Antidepressants Affect Every System in the Body — and Even Leading Withdrawal Researchers Are Missing It

Focusing only on brain chemistry leaves us blind to the bigger picture.

Aug 11 • Brooke Siem

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12

4

July 2025

153. FDA expert panel on SSRIs & pregnancy is a microcosm of the real world

It's never been about the science.

Jul 30 • Brooke Siem

18

4

6

152. Garbage In, Garbage Out: Every Failure of Sameer Jauhar, et.al's New Paper on Antidepressant Withdrawal

The Incidence and Nature of Antidepressant Discontinuation Symptoms: A Systematic Review and Meta-Analysis, published in JAMA Psychiatry

Jul 10 • Brooke Siem

30

6

6

151. What An Emergency Hospital Stay Taught Me About Medical Mistrust

A fever with no diagnosis forced me to navigate the system I’ve spent years questioning.

Jul 3 • Brooke Siem

15

8

June 2025

150. How to Help Hold the FDA Accountable on Antidepressant Risks

Your voice matters. Submit your story to MedWatch.

Jun 3 • Brooke Siem

3