May Cause Side Effects with Brooke Siem

May Cause Side Effects with Brooke Siem

161. Could the Sigma-1 Receptor Explain SSRI Withdrawal?

Exploring a neglected pathway with major implications for tapering

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Brooke Siem
Dec 10, 2025
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The following newsletter, and issues 154-158, are a “translation” of Chris Masterjohn, PhD’s work on serotonin and antidepressants. In a world of rampant plagiarism, it is important to me that credit is given where credit is due. I want to make it clear to the reader that the bulk of the hypotheses and data in this series are credited to Masterjohn and …

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