May Cause Side Effects with Brooke Siem

May Cause Side Effects with Brooke Siem

158. Why SSRIs Aren't Actually Interchangeable

We’ve spent decades chasing “low serotonin,” when we should have been asking which serotonin systems each drug disrupts.

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Brooke Siem
Oct 14, 2025
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A note from Brooke:

The following newsletter, and the four newsletters preceding it, are a “translation” of Chris Masterjohn, PhD’s work on serotonin and antidepressants. In a world of rampant plagiarism, it is important to me that credit is given where credit is due. I want to make it clear to the reader that the bulk of the hypotheses and data in this …

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