May Cause Side Effects with Brooke Siem

May Cause Side Effects with Brooke Siem

156. Why SSRI Withdrawal Feels Systemic: It’s About Energy, Not Emotions

Serotonin’s real job is keeping your cells powered under stress — and SSRIs disrupt that balance. Making sense of Chris Masterjohn's work in the context of antidepressant withdrawal.

Brooke Siem's avatar
Brooke Siem
Sep 16, 2025
∙ Paid

We are currently working through Chris Masterjohn, PhD’s 10-part series on serotonin and how its function (and dysfunction) connects to antidepressant withdrawal.

Because Masterjohn’s work is dense and aimed at an audience with a significant biological and physiological background, I am taking the time to break down his work and explain it in a way that …

User's avatar

Continue reading this post for free, courtesy of Brooke Siem.

Or purchase a paid subscription.
© 2026 brooke.siem · Privacy ∙ Terms ∙ Collection notice
Start your SubstackGet the app
Substack is the home for great culture