May Cause Side Effects with Brooke Siem

May Cause Side Effects with Brooke Siem

154. Antidepressants Affect Every System in the Body — and Even Leading Withdrawal Researchers Are Missing It

Focusing only on brain chemistry leaves us blind to the bigger picture.

Brooke Siem's avatar
Brooke Siem
Aug 11, 2025
∙ Paid

About two months ago, while lying in a hospital bed thanks to a serious virus that left me closer to death than I’ve ever been, I opened an Instagram direct message from a stranger in antidepressant withdrawal who was begging—literally begging—me to save their life.

I looked around the hospital room, examined the IV bruises on both my arms, and said to m…

User's avatar

Continue reading this post for free, courtesy of Brooke Siem.

Or purchase a paid subscription.
© 2026 brooke.siem · Privacy ∙ Terms ∙ Collection notice
Start your SubstackGet the app
Substack is the home for great culture